Protective effects of matrix metalloproteinase-12 following corneal injury
نویسندگان
چکیده
منابع مشابه
Protective effects of matrix metalloproteinase-12 following corneal injury.
Corneal scarring due to injury is a leading cause of blindness worldwide and results from dysregulated inflammation and angiogenesis during wound healing. Here we demonstrate that the extracellular matrix metalloproteinase MMP12 (macrophage metalloelastase) is an important regulator of these repair processes. Chemical injury resulted in higher expression of the fibrotic markers α-smooth muscle ...
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Matrix metalloproteinases (MMP) play an important role in pathogenesis of inflammatory bowel disease (IBD). Two known gelatinases, MMP-2 and MMP-9, are upregulated during IBD. Epithelial-derived MMP-9 is an important mediator of tissue injury in colitis, whereas MMP-2 protects against tissue damage and maintains gut barrier function. It has been suggested that developing strategies to block MMP...
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PURPOSE Corneal alkali injury is highly caustic, and present clinical therapies are limited. The purpose of this study was to investigate the ability of thymosin-beta4 (Taubeta4) to promote healing in an alkali injury model and the mechanisms involved in that process. METHODS Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 ...
متن کاملThymosin- 4 Modulates Corneal Matrix Metalloproteinase Levels and Polymorphonuclear Cell Infiltration after Alkali Injury
METHODS. Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either T 4 or PBS twice daily. At various time points after injury (PI), corneas from the T 4versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expre...
متن کاملRole of Matrix Metalloproteinase Activity in the Neurovascular Protective Effects of Angiotensin Antagonism
Background and Purpose. Oxidative stress and matrix metalloproteinase (MMP) activity have been identified as key mediators of early vascular damage after ischemic stroke. Somewhat surprisingly, the angiotensin II type 1 receptor (AT1) blocker, candesartan, has been shown to acutely increase MMP activity while providing neurovascular protection. We aimed to determine the contribution of MMP and ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2013
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.128033